|Other Names||Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit alpha isoform, PPP3CA, CALNA, CNA|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8463a was selected from the N-term region of human PPP3CA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.|
|Cellular Location||Cell membrane. Cell membrane, sarcolemma. Nucleus. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
PPP3CA is a calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. PPP3CA dephosphorylates HSPB1 and SSH1.
Rodriguez, A., et al., J. Biol. Chem. 280(11):9980-9984 (2005).Shirane, M., et al., Nat. Cell Biol. 5(1):28-37 (2003).Bengoechea-Alonso, M.T., et al., Nitric Oxide 8(1):65-74 (2003).Huai, Q., et al., Proc. Natl. Acad. Sci. U.S.A. 99(19):12037-12042 (2002).Bennasser, Y., et al., Virology 303(1):174-180 (2002).
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