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PPM1B Antibody (Center L76) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O75688
Clone Names 4021124
Peptide ID 4021124
Additional Information
Gene ID 5495
Other Names Protein phosphatase 1B, Protein phosphatase 2C isoform beta, PP2C-beta, PPM1B, PP2CB
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8467a was selected from the Center region of human PPM1B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPM1B
Synonyms PP2CB
Function Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser- 172'. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Cellular Location Cytoplasm, cytosol. Membrane. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization.
Tissue Location Highly expressed in heart and skeletal muscle.
Research Areas
Citations (0)

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PPM1B is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death.


Parvari, R., et al., Genomics 86(2):195-211 (2005).Prajapati, S., et al., J. Biol. Chem. 279(3):1739-1746 (2004).Seroussi, E., et al., J. Mol. Biol. 312(3):439-451 (2001).Hanada, M., et al., J. Biol. Chem. 276(8):5753-5759 (2001).Cheng, A., et al., J. Biol. Chem. 275(44):34744-34749 (2000).

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$ 80.00
Cat# BP8467a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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