|Other Names||Protein phosphatase 1B, Protein phosphatase 2C isoform beta, PP2C-beta, PPM1B, PP2CB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8467a was selected from the Center region of human PPM1B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser- 172'. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.|
|Cellular Location||Cytoplasm, cytosol. Membrane. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization.|
|Tissue Location||Highly expressed in heart and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
PPM1B is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death.
Parvari, R., et al., Genomics 86(2):195-211 (2005).Prajapati, S., et al., J. Biol. Chem. 279(3):1739-1746 (2004).Seroussi, E., et al., J. Mol. Biol. 312(3):439-451 (2001).Hanada, M., et al., J. Biol. Chem. 276(8):5753-5759 (2001).Cheng, A., et al., J. Biol. Chem. 275(44):34744-34749 (2000).
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