|Other Names||Dual specificity protein phosphatase 18, Low molecular weight dual specificity phosphatase 20, LMW-DSP20, DUSP18, LMWDSP20|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8480c was selected from the Center region of human DUSP18. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Widely expressed with highest levels in liver, brain, ovary and testis.|
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Provided below are standard protocols that you may find useful for product applications.
DUSP18 is a member of the dual-specificity phosphatase (DSP) family, which catalyzes dephosphorylation of phosphotyrosine and phosphothreonine residues.
Jeong,D.G., Acta Crystallogr. D Biol. Crystallogr. 62 (PT 6), 582-588 (2006)Wu,Q., Front. Biosci. 11, 2714-2724 (2006)
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