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ARHGAP18 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8N392
Clone Names 90723143
Peptide ID 90723143
Additional Information
Gene ID 93663
Other Names Rho GTPase-activating protein 18, MacGAP, Rho-type GTPase-activating protein 18, ARHGAP18 (HGNC:21035)
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8516c was selected from the Center region of human ARHGAP18. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARHGAP18 (HGNC:21035)
Function Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595).
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Background

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

References

Potkin,S.G., et.al., Mol. Psychiatry 14 (4), 416-428 (2009)Lehner,B.et.al., Genome Res. 14 (7), 1315-1323 (2004)

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$ 80.00
Cat# BP8516c
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