|Other Names||Zinc finger HIT domain-containing protein 1, Cyclin-G1-binding protein 1, Zinc finger protein subfamily 4A member 1, p18 Hamlet, ZNHIT1, CGBP1, ZNFN4A1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8548c was selected from the Center region of human HAMLET. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity.|
|Tissue Location||Expressed abundantly in liver, but weakly in skeletal muscle, ovary and small intestine|
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Provided below are standard protocols that you may find useful for product applications.
ZNHIT1, Zinc finger HIT domain containing protein 1, appears to play a role in p53-mediated apoptosis induction
Lafarga,V.,et.al.,Cell Cycle 6 (19), 2319-2322 (2007)Miele,A.,et.al.,J. Cell. Biochem. 102 (1), 136-148 (2007)Cuadrado,A.,et.al.,EMBO J. 26 (8), 2115-2126 (2007)
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