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> home > Products > Peptides > Biological Process > Metabolic Process > SCAP Antibody (Center) Blocking Peptide
SCAP Antibody (Center) Blocking PeptideSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP8568c | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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SCAP Antibody (Center) Blocking Peptide - Product info | |
| Primary Accession | Q12770 |
| Clone Names | 90723240 |
| Calculated MW | 139729 Da |
SCAP Antibody (Center) Blocking Peptide - Additional info | |
| Gene ID 22937 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP8568c was selected from the Center region of human SCAP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
SCAP Antibody (Center) Blocking Peptide - Protein Information | |
| Name SCAP | |
| Synonyms KIAA0199 | |
| Function Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity) | |
| Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Golgi apparatus membrane; Multi- pass membrane protein (By similarity). Cytoplasmic vesicle, COPII- coated vesicle membrane; Multi-pass membrane protein (By similarity). Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols (By similarity) | |
SCAP Antibody (Center) Blocking Peptide - Related products
AP12299a: SCAP Antibody (N-term)
SCAP Antibody (Center) Blocking Peptide - Research Areas
PeptidesBiological ProcessMetabolic ProcessPrimary Metabolic ProcessCellular ProcessPositive Regulation Of Biological ProcessPositive Regulation Of Cellular ProcessPositive Regulation Of Cellular Metabolic ProcessPositive Regulation Of Metabolic ProcessPositive Regulation Of Macromolecule Metabolic ProcessLipid Metabolic ProcessNegative Regulation Of Biological ProcessPositive Regulation Of Biosynthetic ProcessPositive Regulation Of Cellular Biosynthetic ProcessPositive Regulation Of Macromolecule Biosynthetic ProcessPositive Regulation Of Nitrogen Compound Metabolic ProcessDevelopmental ProcessAlcohol Metabolic Process
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SCAP is a protein with a sterol sensing domain(SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis.
REFERENCES
Lu,Y., et.al., J. Lipid Res. 49 (12), 2582-2589 (2008)
