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PON3 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q15166
Clone Names 90625186
Peptide ID 90625186
Additional Information
Gene ID 5446
Other Names Serum paraoxonase/lactonase 3, PON3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8595a was selected from the N-term region of human PON3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PON3
Function Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
Cellular Location Secreted, extracellular space.
Research Areas
Citations (0)

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PON3 is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis.


Precourt,L.P.,, Int. J. Biochem. Cell Biol. 41 (7), 1628-1637 (2009)Mackness,B.,, Curr. Opin. Lipidol. 13 (4), 357-362 (2002)

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$ 80.00
Cat# BP8595a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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