|Other Names||Protein sel-1 homolog 1, Suppressor of lin-12-like protein 1, Sel-1L, SEL1L, TSA305|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8599c was selected from the Center region of human SEL1L. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
SEL1L may play a role in Notch signaling and be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.
Mueller,B., et.al., Proc. Natl. Acad. Sci. U.S.A. 105 (34), 12325-12330 (2008)Cattaneo,M., et.al., J. Biol. Chem. 284 (17), 11405-11415 (2009)Riemer,J., et.al., Proc. Natl. Acad. Sci. U.S.A. 106 (35), 14831-14836 (2009)
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