|Other Names||Retinal dehydrogenase 2, RALDH 2, RalDH2, Aldehyde dehydrogenase family 1 member A2, Retinaldehyde-specific dehydrogenase type 2, RALDH(II), ALDH1A2, RALDH2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8609b was selected from the C-term region of human ALDH1A2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
ALDH1A2 belongs to the aldehyde dehydrogenase family of proteins. This protein is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida.
Kim,H., et.al., Cancer Res. 65 (18), 8118-8124 (2005)Niederreither,K., et.al., Nat. Genet. 31 (1), 84-88 (2002)
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