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GAPDHS Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O14556 |
|---|---|
| Clone Names | 80513154 |
| Gene ID | 26330 |
|---|---|
| Other Names | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific, Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2, GAPDH-2, Spermatogenic glyceraldehyde-3-phosphate dehydrogenase, GAPDHS, GAPD2, GAPDH2, GAPDS |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8610c was selected from the Center region of human GAPDHS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GAPDHS |
|---|---|
| Synonyms | GAPD2, GAPDH2, GAPDS |
| Function | May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Testis specific. |
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Provided below are standard protocols that you may find useful for product applications.
Background
GAPDHS is a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility.
References
Welch,J.E., et.al., J. Androl. 21 (2), 328-338 (2000)Goodwin,L.O., et.al., Mol. Hum. Reprod. 6 (2), 127-136 (2000)Benham,F.J. et.al., Genomics 5 (2), 209-214 (1989)
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