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DPPA2 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q7Z7J5
Clone Names 70305168
Peptide ID 70305168
Additional Information
Other Names Developmental pluripotency-associated protein 2, Pluripotent embryonic stem cell-related gene 1 protein, DPPA2, PESCRG1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8642d was selected from the N-term region of human DPPA2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DPPA2
Synonyms PESCRG1
Function Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes.
Cellular Location Nucleus.
Tissue Location Expressed in embryonic stem cells. No expression is seen in 5 months embryo, mesenchymal stem cells, embryonic fibrocytes and adult tissues EMBL; AY283672; AAP37285.1; -; mRNA EMBL; BC018070; AAH18070.1; -; mRNA CCDS; CCDS2956.1; - RefSeq; NP_620170.3; NM_138815.3 RefSeq; XP_011510746.1; XM_011512444.2 RefSeq; XP_011510747.1; XM_011512445.2 UniGene; Hs.351113; - ProteinModelPortal; Q7Z7J5; - SMR; Q7Z7J5; - BioGrid; 127407; 21 IntAct; Q7Z7J5; 17 STRING; 9606.ENSP00000417710; - iPTMnet; Q7Z7J5; - PhosphoSitePlus; Q7Z7J5; - SwissPalm; Q7Z7J5; - BioMuta; DPPA2; - DMDM; 116241341; - EPD; Q7Z7J5; - MaxQB; Q7Z7J5; - PaxDb; Q7Z7J5; - PeptideAtlas; Q7Z7J5; - PRIDE; Q7Z7J5; - ProteomicsDB; 69552; - DNASU; 151871; - Ensembl; ENST00000478945; ENSP00000417710; ENSG00000163530 GeneID; 151871; - KEGG; hsa:151871; - UCSC; uc003dxo.3; human CTD; 151871; - DisGeNET; 151871; - EuPathDB; HostDB:ENSG00000163530.4; - GeneCards; DPPA2; - HGNC; HGNC:19197; DPPA2 HPA; HPA036134; - MIM; 614445; gene neXtProt; NX_Q7Z7J5; - OpenTargets; ENSG00000163530; - PharmGKB; PA134944028; - eggNOG; ENOG410IJEN; Eukaryota eggNOG; ENOG4111ADR; LUCA GeneTree; ENSGT00390000004871; - HOGENOM; HOG000060113; - HOVERGEN; HBG095578; - InParanoid; Q7Z7J5; - OMA; TLRDWCQ; - OrthoDB; EOG091G0QL3; - PhylomeDB; Q7Z7J5; - TreeFam; TF338129; - GeneWiki; Developmental_pluripotency_associated_2; - GenomeRNAi; 151871; - PRO; PR:Q7Z7J5; - Proteomes; UP000005640; Chromosome 3 Bgee; ENSG00000163530; - CleanEx; HS_DPPA2; - Genevisible; Q7Z7J5; HS GO; GO:0005634; C:nucleus; IDA:HPA GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW InterPro; IPR025891; Dppa2/4_C_dom InterPro; IPR025892; Dppa2/4_central_dom InterPro; IPR003034; SAP_dom Pfam; PF14047; DCR; 1 Pfam; PF14049; Dppa2_A; 1 PROSITE; PS50800; SAP; 1 2: Evidence at transcript level; Complete proteome; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation CHAIN 1 298 Developmental pluripotency-associated protein 2 /FTId=PRO_0000239263 DOMAIN 92 126 SAP. {ECO:0000255|PROSITE- ProRule:PRU00186} VARIANT 131 131 R -> Q (in dbSNP:rs9809030) /FTId=VAR_028087 CONFLICT 89 89 L -> S (in Ref. 1; AAP37285) SEQUENCE 298 AA; 33784 MW; 87FBCCCF52E88B5D CRC64; MSDANLDSSK KNFLEGEVDD EESVILTLVP VKDDANMEQM EPSVSSTSDV KLEKPKKYNP GHLLQTNEQF TAPQKARCKI PALPLPTILP PINKVCRDTL RDWCQQLGLS TNGKKIEVYL RLHRHAYPEQ RQDMPEMSQE TRLQRCSRKR KAVTKRARLQ RSYEMNERAE ETNTVEVITS APGAMLASWA RIAARAVQPK ALNSCSIPVS VEAFLMQASG VRWCVVHGRL LSADTKGWVR LQFHAGQAWV PTTHRRMISL FLLPACIFPS PGIEDNMLCP DCAKRNKKMM KRLMTVEK
Research Areas
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Background

DPPA2 may play a role in maintaining cell pluripotentiality.

References

John,T., et.al., Clin. Cancer Res. 14 (11), 3291-3298 (2008)Monk,M., et.al., Mol. Hum. Reprod. 14 (6), 347-355 (2008)

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$ 80.00
Cat# BP8642d
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