|Other Names||Ferrochelatase, mitochondrial, Heme synthase, Protoheme ferro-lyase, FECH|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8657a was selected from the N-term region of human FECH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the ferrous insertion into protoporphyrin IX.|
|Cellular Location||Mitochondrion inner membrane; Peripheral membrane protein; Matrix side|
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Provided below are standard protocols that you may find useful for product applications.
FECH is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway.
Nakahashi,Y., et.al., Proc. Natl. Acad. Sci. U.S.A. 89 (1), 281-285 (1992)Brenner,D.A., et.al., Am. J. Hum. Genet. 50 (6), 1203-1210 (1992)
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