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FLCN Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8NFG4
Clone Names 90121121
Peptide ID 90121121
Additional Information
Gene ID 201163
Other Names Folliculin, BHD skin lesion fibrofolliculoma protein, Birt-Hogg-Dube syndrome protein, FLCN, BHD
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8658c was selected from the Center region of human FLCN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FLCN
Synonyms BHD
Function May play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). May be a tumor suppressor. May be involved in colorectal tumorigenesis. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.
Cellular Location Cytoplasm. Nucleus. Note=Mainly localized in the nucleus. Colocalizes with FNIP1 and FNIP2 in the cytoplasm
Tissue Location Expressed in most tissues tested, including skin, lung, kidney, heart, testis and stomach
Research Areas
Citations (0)

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Background

FLCN may play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). FLCN may be a tumor suppressor. May be involved in colorectal tumorigenesis. It may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways.

References

Khoo,S.K., et.al., J. Med. Genet. 39 (12), 906-912 (2002)Shin,J.H., et.al., J. Med. Genet. 40 (5), 364-367 (2003)

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$ 80.00
Cat# BP8658c
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