|Other Names||B-cell scaffold protein with ankyrin repeats, BANK1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8667c was selected from the Center region of human BANK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2.|
|Tissue Location||Expressed in B-cell but not T-cell or myeloid cell lines. Highest expression in CD19(+) B-cells, with very low expression in other cell populations|
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Provided below are standard protocols that you may find useful for product applications.
BANK1 is a B-cell-specific scaffold protein and LYN (MIM 165120) tyrosine kinase substrate that promotes tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors.
Orozco,G., et.al., Arthritis Rheum. 60 (2), 372-379 (2009)Guo,L., et.al., Genes Immun. 10 (5), 531-538 (2009)
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