CNTNAP2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UHC6 |
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Clone Names | 90904118 |
Gene ID | 26047 |
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Other Names | Contactin-associated protein-like 2, Cell recognition molecule Caspr2, CNTNAP2, CASPR2 {ECO:0000303|PubMed:10624965}, KIAA0868 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8701c was selected from the Center region of human CNTNAP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CNTNAP2 |
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Synonyms | CASPR2 {ECO:0000303|PubMed:10624965}, KI |
Function | Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction. |
Cellular Location | Membrane {ECO:0000250|UniProtKB:Q9CPW0}; Single- pass type I membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:Q9CPW0}. Cell junction, paranodal septate junction {ECO:0000250|UniProtKB:Q9CPW0}. Note=Expressed in the juxtaparadonal region. {ECO:0000250|UniProtKB:Q9CPW0} |
Tissue Location | Predominantly expressed in nervous system. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CNTNAP2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C omain,discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons.
References
Denisenko-Nehrbass,N., et.al., Eur. J. Neurosci. 17 (2), 411-416 (2003)Nakayama,M., et.al., Genome Res. 12 (11), 1773-1784 (2002)
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