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CNTNAP2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UHC6
Clone Names 90904118
Peptide ID 90904118
Additional Information
Gene ID 26047
Other Names Contactin-associated protein-like 2, Cell recognition molecule Caspr2, CNTNAP2, CASPR2 {ECO:0000303|PubMed:10624965}, KIAA0868
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8701c was selected from the Center region of human CNTNAP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CNTNAP2
Synonyms CASPR2 {ECO:0000303|PubMed:10624965}, KI
Function May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction (By similarity).
Cellular Location Membrane {ECO:0000250|UniProtKB:Q9CPW0}; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:Q9CPW0}
Tissue Location Predominantly expressed in nervous system.
Research Areas
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Background

CNTNAP2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C omain,discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons.

References

Denisenko-Nehrbass,N., et.al., Eur. J. Neurosci. 17 (2), 411-416 (2003)Nakayama,M., et.al., Genome Res. 12 (11), 1773-1784 (2002)

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$ 80.00
Cat# BP8701c
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