NOP2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P46087 |
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Other Accession | NP_006161 |
Clone Names | 91023036 |
Gene ID | 4839 |
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Other Names | Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase, 211-, Nucleolar protein 1, Nucleolar protein 2 homolog, Proliferating-cell nucleolar antigen p120, Proliferation-associated nucleolar protein p120, NOP2, NOL1, NSUN1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8773a was selected from the N-term region of human NOP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NOP2 |
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Synonyms | NOL1, NSUN1 |
Function | Involved in ribosomal large subunit assembly (PubMed:24120868). S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable). |
Cellular Location | Nucleus, nucleolus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
NOP2 may play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase.
References
Mayya V., et.al., Sci. Signal. 2:RA46-RA46(2009).
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