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ADSL Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P30566
Clone Names 90429011
Peptide ID 90429011
Additional Information
Gene ID 158
Other Names Adenylosuccinate lyase, ASL, Adenylosuccinase, ASase, ADSL, AMPS
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8807c was selected from the Center region of human ADSL. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms AMPS
Function Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
Tissue Location Ubiquitously expressed. Both isoforms are produced by all tissues. Isoform 2 is 10-fold less abundant than isoform 1
Research Areas
Citations (0)

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Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy.


Stone,R.L.,, J. Biol. Chem. 268 (26), 19710-19716 (1993)Mouchegh,K.,, J. Pediatr. 150 (1), 57-61 (2007)

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$ 80.00
Cat# BP8807c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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