COTL1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q14019 |
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Other Accession | NP_066972 |
Clone Names | 91023147 |
Gene ID | 23406 |
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Other Names | Coactosin-like protein, COTL1, CLP |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8819b was selected from the C-term region of human COTL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | COTL1 |
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Synonyms | CLP |
Function | Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. |
Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Nucleus |
Tissue Location | Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
COTL1 is one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis.
References
Provost,P., et.al., Proc. Natl. Acad. Sci. U.S.A. 96 (5), 1881-1885 (1999)Provost,P., et.al., J. Biol. Chem. 276 (19), 16520-16527 (2001)
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