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COTL1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q14019
Other Accession NP_066972
Clone Names 91023147
Peptide ID 91023147
Additional Information
Gene ID 23406
Other Names Coactosin-like protein, COTL1, CLP
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8819b was selected from the C-term region of human COTL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name COTL1
Synonyms CLP
Function Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.
Cellular Location Cytoplasm, cytoskeleton. Nucleus membrane; Peripheral membrane protein
Tissue Location Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas
Research Areas
Citations (0)

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COTL1 is one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis.


Provost,P.,, Proc. Natl. Acad. Sci. U.S.A. 96 (5), 1881-1885 (1999)Provost,P.,, J. Biol. Chem. 276 (19), 16520-16527 (2001)

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$ 80.00
Cat# BP8819b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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