|Other Names||Coactosin-like protein, COTL1, CLP|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8819b was selected from the C-term region of human COTL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Nucleus|
|Tissue Location||Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
COTL1 is one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis.
Provost,P., et.al., Proc. Natl. Acad. Sci. U.S.A. 96 (5), 1881-1885 (1999)Provost,P., et.al., J. Biol. Chem. 276 (19), 16520-16527 (2001)
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