|Other Names||Calpain-12, 3422-, Calcium-activated neutral proteinase 12, CANP 12, CAPN12|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8838a was selected from the N-term region of human CAN12. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-regulated non-lysosomal thiol-protease.|
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Provided below are standard protocols that you may find useful for product applications.
Calpains are a family of cytosolic calcium-activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin-cytoskeletal interactions, and synaptic plasticity (Dear et al., 2000 [PubMed 10964513]). CAPN12 belongs to the calpain large subunit family.[supplied by OMIM].
Dear,T.N., et.al., Genomics 68 (2), 152-160 (2000)
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