|Other Names||Collagen alpha-1(XVIII) chain, Endostatin, COL18A1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8852a was selected from the N-term region of human COL18A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Present in multiple organs with highest levels in liver, lung and kidney|
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Provided below are standard protocols that you may find useful for product applications.
COL18A1 is encoding the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein.
Fu,Y.,et.al., Biochemistry 48 (49), 11655-11663 (2009)
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