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COPS5 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q92905
Clone Names 90921002
Peptide ID 90921002
Additional Information
Gene ID 10987
Other Names COP9 signalosome complex subunit 5, SGN5, Signalosome subunit 5, 34--, Jun activation domain-binding protein 1, COPS5, CSN5, JAB1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8867b was selected from the C-term region of human COPS5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name COPS5
Synonyms CSN5, JAB1
Function Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.
Cellular Location Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle Note=Nuclear localization is diminished in the presence of IFIT3
Research Areas
Citations (0)

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The protein is one of the eight subunits of COP9 signalosome, a highly onserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.


Nishimoto,A.,, Biochem. Biophys. Res. Commun. 391 (4), 1616-1622 (2010)

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$ 80.00
Cat# BP8867b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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