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ALOX12 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P18054
Clone Names 80311176
Peptide ID 80311176
Additional Information
Gene ID 239
Other Names Arachidonate 12-lipoxygenase, 12S-type, 12S-LOX, 12S-lipoxygenase, Lipoxin synthase 12-LO, 332-, Platelet-type lipoxygenase 12, ALOX12, 12LO, LOG12
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8877a was selected from the N-term region of human ALOX12. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALOX12
Synonyms 12LO, LOG12
Function Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.
Cellular Location Cytoplasm, cytosol. Membrane. Note=Membrane association is stimulated by EGF
Tissue Location Expressed in vascular smooth muscle cells.
Research Areas
Citations (0)

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Oxygenase and 14,15-leukotriene A4 synthase activity.


Yoshimoto,T.,, Biochem. Biophys. Res. Commun. 172 (3), 1230-1235 (1990)

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$ 80.00
Cat# BP8877a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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