|Other Names||Sphingomyelin phosphodiesterase, Acid sphingomyelinase, aSMase, SMPD1, ASM|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8882b was selected from the C-term region of human SMPD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Converts sphingomyelin to ceramide (PubMed:1840600, PubMed:18815062, PubMed:27659707, PubMed:25920558). Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.|
|Cellular Location||Lysosome. Secreted|
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Provided below are standard protocols that you may find useful for product applications.
SMPD1 is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. This protein also has phospholipase C activity.
Takahashi,T., et.al., Hum. Mutat. 1 (1), 70-71 (1992)
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