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LDLR Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P01130
Clone Names 90504091
Peptide ID 90504091
Additional Information
Gene ID 3949
Other Names Low-density lipoprotein receptor, LDL receptor, LDLR
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8960c was selected from the Center region of human LDLR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
Cellular Location Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein Membrane, clathrin-coated pit; Single-pass type I membrane protein. Golgi apparatus. Early endosome. Late endosome. Cell surface. Lysosome. Note=Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9
Research Areas
Citations (0)

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The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place.


Hobbs,H.H.,, Hum. Mutat. 1 (6), 445-466 (1992)Brown,M.S., Proc. Natl. Acad. Sci. U.S.A. 76 (7), 3330-3337 (1979)

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$ 80.00
Cat# BP8960c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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