|Other Names||Pre-mRNA 3'-end-processing factor FIP1, hFip1, FIP1-like 1 protein, Factor interacting with PAP, Rearranged in hypereosinophilia, FIP1L1, FIP1, RHE|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8985b was selected from the C-term region of human FIP1L1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex.|
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Provided below are standard protocols that you may find useful for product applications.
FIP1L1 is a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors.
Griffin,J.H., et.al., Proc. Natl. Acad. Sci. U.S.A. 100 (13), 7830-7835 (2003)
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