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SCG5 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P05408
Clone Names 90723110
Peptide ID 90723110
Additional Information
Gene ID 6447
Other Names Neuroendocrine protein 7B2, Pituitary polypeptide, Secretogranin V, Secretogranin-5, Secretory granule endocrine protein I, N-terminal peptide, C-terminal peptide, SCG5, SGNE1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9012b was selected from the C-term region of human SCG5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCG5
Synonyms SGNE1
Function Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
Cellular Location Secreted. Note=Neuroendocrine and endocrine secretory granules
Research Areas
Citations (0)

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Background

SCG5 acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. It binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. It plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.

References

Brayton,K.A., et.al., DNA 7 (10), 713-719 (1988)

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$ 80.00
Cat# BP9012b
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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