|Other Names||Dual specificity protein phosphatase 19, Dual specificity phosphatase TS-DSP1, Low molecular weight dual specificity phosphatase 3, LMW-DSP3, Protein phosphatase SKRP1, Stress-activated protein kinase pathway-regulating phosphatase 1, SAPK pathway-regulating phosphatase 1, DUSP19, DUSP17, LMWDSP3, SKRP1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9029a was selected from the N-term region of human DUSP19. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DUSP17, LMWDSP3, SKRP1|
|Function||Has a dual specificity toward Ser/Thr and Tyr-containing proteins.|
|Tissue Location||Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the highest|
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Provided below are standard protocols that you may find useful for product applications.
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714).
Cheng,H., et.al., Int. J. Biochem. Cell Biol. 35 (2), 226-234 (2003)
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