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SFRP1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8N474
Clone Names 90713245
Peptide ID 90713245
Additional Information
Gene ID 6422
Other Names Secreted frizzled-related protein 1, FRP-1, sFRP-1, Secreted apoptosis-related protein 2, SARP-2, SFRP1, FRP, FRP1, SARP2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9037a was selected from the N-term region of human SFRP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SFRP1
Synonyms FRP, FRP1, SARP2
Function Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
Cellular Location Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding
Tissue Location Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes
Research Areas
Citations (0)

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SFRP1 encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer.


Huang,D.,, J. Cancer Res. Clin. Oncol. 136 (3), 395-401 (2010);Yang,Z.Q.,, Int. J. Cancer 125 (7), 1613-1621 (2009).

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$ 80.00
Cat# BP9037a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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