|Other Names||Cornifin-B, 149 kDa pancornulin, Small proline-rich protein IB, SPR-IB, SPRR1B|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9052b was selected from the C-term region of human SPRR1B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage.|
|Tissue Location||Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea|
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Provided below are standard protocols that you may find useful for product applications.
SPRR1B is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage.
Stemmler,S., et.al., Int. J. Immunogenet. 36 (4), 217-222 (2009)Kainu,K., et.al., Exp. Dermatol. 18 (2), 109-115 (2009)
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