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SPRR1B Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P22528 |
|---|---|
| Clone Names | 91023184 |
| Gene ID | 6699 |
|---|---|
| Other Names | Cornifin-B, 149 kDa pancornulin, Small proline-rich protein IB, SPR-IB, SPRR1B |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9052b was selected from the C-term region of human SPRR1B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SPRR1B |
|---|---|
| Function | Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea |
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Provided below are standard protocols that you may find useful for product applications.
Background
SPRR1B is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage.
References
Stemmler,S., et.al., Int. J. Immunogenet. 36 (4), 217-222 (2009)Kainu,K., et.al., Exp. Dermatol. 18 (2), 109-115 (2009)
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