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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   AHRR Antibody (Center) Blocking peptide   

AHRR Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession A9YTQ3
Clone Names 90819084
Peptide ID 90819084
Additional Information
Gene ID 57491
Other Names Aryl hydrocarbon receptor repressor, AhR repressor, AhRR, Class E basic helix-loop-helix protein 77, bHLHe77, AHRR, BHLHE77, KIAA1234
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9065c was selected from the Center region of human AHRR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms BHLHE77, KIAA1234
Function Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
Cellular Location Cytoplasm. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:17980155}. Note=Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment
Tissue Location Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary.
Research Areas
Citations (0)

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AHRR encoded by this gene represses signal transduction by the arylhydrocarbon receptor by competing with the arylhydrocarbon receptor nuclear translocator for binding to the arylhydrocarbon receptor. Expression of the repressor is stimulated by the receptor/translocator heterodimer, thereby regulating receptor function through a negative feedback mechanism. In addition, the encoded protein can bind to nuclear factor kappa-B.


Davila,S.,, Genes Immun. (2010) In pressAsada,H.,, Fertil. Steril. 92 (4), 1240-1242 (2009)

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$ 80.00
Cat# BP9065c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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