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SH2D1B Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O14796
Clone Names 90504151
Peptide ID 90504151
Additional Information
Gene ID 117157
Other Names SH2 domain-containing protein 1B, EWS/FLI1-activated transcript 2, EAT-2, SH2D1B, EAT2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9126c was selected from the Center region of human SH2D1B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SH2D1B
Synonyms EAT2
Function Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity). In the context of NK cell- mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule- organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958). Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity).
Research Areas
Citations (0)

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Background

SH2D1B plays a role in controlling signal transduction through at least four receptors, CD84, CD150, CD229 and CD244, expressed on the surface of professional antigen-presenting cells.

References

Morra,M., et.al., Annu. Rev. Immunol. 19, 657-682 (2001)Tangye,S.G., et.al., Eur. J. Immunol. 32 (6), 1640-1649 (2002)

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$ 80.00
Cat# BP9126c
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