|Other Names||Ecotropic viral integration site 5 protein homolog, EVI-5, Neuroblastoma stage 4S gene protein, EVI5, NB4S|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9168c was selected from the Center region of human EVI5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis|
|Tissue Location||Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal.|
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Provided below are standard protocols that you may find useful for product applications.
EVI5 is a novel centrosomal protein with a complex expression pattern and subcellular localization, possibly involved in centrosome stability and dynamics. It may act as an oncogene.
Jacob,B., et.al., Blood 115 (8), 1610-1620 (2010)Hoppenbrouwers,I.A., et.al., J. Hum. Genet. 54 (11), 676-680 (2009)
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