|Other Names||Peroxisomal membrane protein PMP34, 34 kDa peroxisomal membrane protein, Solute carrier family 25 member 17, SLC25A17, PMP34|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9172a was selected from the N-term region of human SLC25A17. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'- diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter- exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro.|
|Cellular Location||Cytoplasm. Peroxisome membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitous. Expressed in liver.|
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Provided below are standard protocols that you may find useful for product applications.
This protein encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response.
McGeachie,M., et.al., Circulation 120 (24), 2448-2454 (2009)Kelly,E., et.al., J. Biol. Chem. 284 (25), 16891-16897 (2009)
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