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AIFM3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96NN9 |
|---|---|
| Clone Names | 90909011 |
| Gene ID | 150209 |
|---|---|
| Other Names | Apoptosis-inducing factor 3, 1---, Apoptosis-inducing factor-like protein, AIFM3, AIFL |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9174b was selected from the C-term region of human AIFM3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | AIFM3 |
|---|---|
| Synonyms | AIFL |
| Function | Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential. |
| Cellular Location | Mitochondrion. Note=Does not translocate to the nucleus upon induction of apoptosis |
| Tissue Location | Ubiquitous. Expressed in bone marrow, cerebral cortex, liver, ovary, thymus, thyroid gland and tongue (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This protein encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma.
References
Vierimaa,O., et.al., J. Endocrinol. Invest. 32 (6), 512-518 (2009)Hahn,M.A., et.al., J. Endocrinol. 201 (3), 387-396 (2009)
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