|Other Names||Dystrobrevin beta, DTN-B, Beta-dystrobrevin, DTNB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9187b was selected from the C-term region of human DTNB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Highly expressed in brain, kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
DTNB encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin.
Gudbjartsson,D.F., et.al., Nat. Genet. 40 (5), 609-615 (2008)Nazarian,R., et.al., Biochem. J. 395 (3), 587-598 (2006)
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