|Other Names||MAGUK p55 subfamily member 6, Veli-associated MAGUK 1, VAM-1, MPP6, VAM1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9201c was selected from the Center region of human MPP6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Membrane; Peripheral membrane protein|
|Tissue Location||Abundant in testis, brain, and kidney with lower levels detectable in other tissues|
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Provided below are standard protocols that you may find useful for product applications.
Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily.
Scheel,A.K., et.al., Ann. Rheum. Dis. 65 (5), 595-600 (2006)Rush,J., et.al., Nat. Biotechnol. 23 (1), 94-101 (2005)Rush,J., et.al., Nat. Biotechnol. 23 (1), 94-101 (2005)
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