|Other Names||Claudin-8, CLDN8|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9222c was selected from the Center region of human CLDN8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a major role in tight junction-specific obliteration of the intercellular space.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Localizes to tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, and in the corpus at the interface between basal and principal cells|
|Tissue Location||Expressed in the epididymis, mainly in the caput segment.|
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Provided below are standard protocols that you may find useful for product applications.
CLDN8 is components of epithelial cell tight junctions. Tight junctions regulate movement of solutes and ions through the paracellular space and prevent mixing of proteins and lipids in the outer leaflet of the apical and basolateral plasma membrane domains
Kim,S.S., et.al., Histopathology 54 (5), 633-635 (2009)Osunkoya,A.O., et.al, Hum. Pathol. 40 (2), 206-210 (2009)
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