CLDN8 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P56748 |
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Clone Names | 90909137 |
Gene ID | 9073 |
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Other Names | Claudin-8, CLDN8 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9222c was selected from the Center region of human CLDN8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CLDN8 (HGNC:2050) |
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Function | Tight-junction protein required for paracellular chloride transport in the kidney. Mediates recruitment of CLDN4 to tight junction in the kidney. Claudins play a major role in tight junction- specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. |
Cellular Location | Cell junction, tight junction. Cell membrane {ECO:0000250|UniProtKB:Q9Z260}; Multi-pass membrane protein. Note=Localizes to tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, and in the corpus at the interface between basal and principal cells. |
Tissue Location | Expressed in the epididymis, mainly in the caput segment. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CLDN8 is components of epithelial cell tight junctions. Tight junctions regulate movement of solutes and ions through the paracellular space and prevent mixing of proteins and lipids in the outer leaflet of the apical and basolateral plasma membrane domains
References
Kim,S.S., et.al., Histopathology 54 (5), 633-635 (2009)Osunkoya,A.O., et.al, Hum. Pathol. 40 (2), 206-210 (2009)
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