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PINX1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96BK5
Clone Names 90909183
Peptide ID 90909183
Additional Information
Gene ID 54984
Other Names PIN2/TERF1-interacting telomerase inhibitor 1, Liver-related putative tumor suppressor, Pin2-interacting protein X1, Protein 67-11-3, TRF1-interacting protein 1, PINX1, LPTL, LPTS
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9227c was selected from the Center region of human PINX1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PINX1
Synonyms LPTL, LPTS
Function Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
Cellular Location Nucleus. Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Note=Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE
Tissue Location Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines
Research Areas
Citations (0)

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PINX1 (PIN2-interacting protein 1) is a ubiquitously expressed protein that localizes to nucleoli and telomere speckles. It contains a TID (telomerase inhibiting domain) domain which is capable of binding MCRS1, TERT and TERF1 and has been shown to be a potent telomerase inhibitor and putative tumor suppressor.


Shen,J.,, Cancer Epidemiol. Biomarkers Prev. 19 (1), 219-228 (2010)Yuan,K.,, J. Biol. Chem. 284 (34), 23072-23082 (2009)

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$ 80.00
Cat# BP9227c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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