|Other Names||Acylglycerol kinase, mitochondrial, hAGK, Multiple substrate lipid kinase, HsMuLK, MuLK, Multi-substrate lipid kinase, AGK, MULK|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9238b was selected from the C-term region of human AGK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.|
|Cellular Location||Mitochondrion membrane|
|Tissue Location||Highly expressed in muscle, heart, kidney and brain.|
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Provided below are standard protocols that you may find useful for product applications.
AGK can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively.
Nouh,M.A., et.al, Cancer Sci. 100 (9), 1631-1638 (2009)Epand,R.M., et.al, Biochemistry 46 (49), 14225-14231 (2007)
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