SNF2L Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P28370 |
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Clone Names | 81201025 |
Gene ID | 6594 |
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Other Names | Probable global transcription activator SNF2L1, 364-, ATP-dependent helicase SMARCA1, Nucleosome-remodeling factor subunit SNF2L, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1, SMARCA1, SNF2L, SNF2L1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9257b was selected from the C-term region of human SNF2L. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SMARCA1 |
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Synonyms | SNF2L, SNF2L1 |
Function | [Isoform 1]: Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity (PubMed:15310751, PubMed:28801535). Acts as a negative regulator of chromatin remodelers by generating inactive complexes (PubMed:15310751). |
Cellular Location | Nucleus. |
Tissue Location | [Isoform 1]: Mainly expressed in non-neuronal tissues such as lung, breast, kidney, and ovary |
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Provided below are standard protocols that you may find useful for product applications.
Background
SNF2L encodes a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes.
References
Ye,Y., et.al., Mol. Cancer Res. 7 (12), 1984-1999 (2009)Xia,Y., et.al., Biochem. Biophys. Res. Commun. 368 (2), 438-444 (2008)Lazzaro,M.A., et.al., BMC Med. Genet. 9, 11 (2008)
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