|Other Names||Probable global transcription activator SNF2L1, 364-, ATP-dependent helicase SMARCA1, Nucleosome-remodeling factor subunit SNF2L, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1, SMARCA1, SNF2L, SNF2L1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9257b was selected from the C-term region of human SNF2L. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Energy-transducing component of NURF (nucleosome- remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilitate the perturbation of chromatin structure in an ATP-dependent manner. Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression. May be involved in the development of luteal cells.|
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Provided below are standard protocols that you may find useful for product applications.
SNF2L encodes a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes.
Ye,Y., et.al., Mol. Cancer Res. 7 (12), 1984-1999 (2009)Xia,Y., et.al., Biochem. Biophys. Res. Commun. 368 (2), 438-444 (2008)Lazzaro,M.A., et.al., BMC Med. Genet. 9, 11 (2008)
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