|Other Names||Mitochondrial uncoupling protein 4, UCP 4, Solute carrier family 25 member 27, SLC25A27, UCP4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9260c was selected from the Center region of human SLC25A27. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein|
|Tissue Location||Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal chord, corpus callosum and substantia nigra|
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Provided below are standard protocols that you may find useful for product applications.
SLC25A27 is members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells.
Chu,A.C., et.al, Free Radic. Biol. Med. 46 (6), 810-820 (2009)Szolnoki,Z., et.al, Neuromolecular Med. 11 (2), 101-105 (2009)Starr,J.M., et.al, Mech. Ageing Dev. 129 (12), 745-751 (2008)
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