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ACCN2 Antibody (C-term) Blocking PeptideSynthetic peptide
| Country | United States
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| Catalog # | Size | Availability | Price | |
| BP9270b | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
ACCN2 Antibody (C-term) Blocking Peptide - Product info | |
| Primary Accession | P78348 |
| Clone Names | 90805002 |
| Calculated MW | 59909 Da |
ACCN2 Antibody (C-term) Blocking Peptide - Additional info | |
| Gene ID 41 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP9270b was selected from the C-term region of human ACCN2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
ACCN2 Antibody (C-term) Blocking Peptide - Protein Information | |
| Name ASIC1 | |
| Synonyms ACCN2, BNAC2 | |
| Function Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury Heteromeric channel assembly seems to modulate channel properties Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear (By similarity) | |
| Cellular Location Cell membrane; Multi-pass membrane protein (By similarity). Note=Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4 (By similarity) | |
| Tissue Location Expressed in most or all neurons. | |
ACCN2 Antibody (C-term) Blocking Peptide - Related products
AP9270b: ACCN2 Antibody (C-term)
RI10052: ACCN2 predesign siRNA
ACCN2 Antibody (C-term) Blocking Peptide - Research Areas
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BACKGROUND
ACCN2 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown.
REFERENCES
Sherwood,T., et.al, J. Biol. Chem. 284 (41), 27899-27907 (2009)Kapoor,N., et.al, J. Biol. Chem. 284 (36), 24526-24541 (2009)Samways,D.S., et.al., Cell Calcium 45 (4), 319-325 (2009)
