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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   ACCN2 Antibody (C-term) Blocking Peptide   

ACCN2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P78348
Clone Names 90805002
Peptide ID 90805002
Additional Information
Gene ID 41
Other Names Acid-sensing ion channel 1, ASIC1, Amiloride-sensitive cation channel 2, neuronal, Brain sodium channel 2, BNaC2, ASIC1, ACCN2, BNAC2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9270b was selected from the C-term region of human ACCN2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ASIC1
Synonyms ACCN2, BNAC2
Function Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
Cellular Location Cell membrane; Multi- pass membrane protein Note=Localizes in synaptosomes at dendritic synapses of neurons Colocalizes with DLG4 (By similarity).
Tissue Location Expressed in most or all neurons.
Research Areas
Citations (0)

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ACCN2 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown.


Sherwood,T.,, J. Biol. Chem. 284 (41), 27899-27907 (2009)Kapoor,N.,, J. Biol. Chem. 284 (36), 24526-24541 (2009)Samways,D.S.,, Cell Calcium 45 (4), 319-325 (2009)

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$ 80.00
Cat# BP9270b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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