|Other Names||BTB/POZ domain-containing protein KCTD12, Pfetin, Predominantly fetal expressed T1 domain, KCTD12, C13orf2, KIAA1778, PFET1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9273c was selected from the Center region of human KCTD12. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||C13orf2, KIAA1778, PFET1|
|Function||Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).|
|Cellular Location||Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane|
|Tissue Location||Present in a variety of fetal organs, with highest expression levels in the cochlea and brain and, in stark contrast, is detected only at extremely low levels in adult organs, such as brain and lung.|
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Provided below are standard protocols that you may find useful for product applications.
Drenos,F., et.al., Hum. Mol. Genet. 18 (12), 2305-2316 (2009)Suehara,Y., et.al., Clin. Cancer Res. 14 (6), 1707-1717 (2008)Cauchi,S., et.al., J. Mol. Med. 86 (3), 341-348 (2008)
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