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KCTD12 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96CX2
Clone Names 90723068
Peptide ID 90723068
Additional Information
Other Names BTB/POZ domain-containing protein KCTD12, Pfetin, Predominantly fetal expressed T1 domain, KCTD12, C13orf2, KIAA1778, PFET1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9273c was selected from the Center region of human KCTD12. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCTD12
Synonyms C13orf2, KIAA1778, PFET1
Function Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).
Cellular Location Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane
Tissue Location Present in a variety of fetal organs, with highest expression levels in the cochlea and brain and, in stark contrast, is detected only at extremely low levels in adult organs, such as brain and lung. EMBL; AF359381; AAQ15187.1; -; mRNA EMBL; BC013764; AAH13764.1; -; mRNA CCDS; CCDS9455.1; - RefSeq; NP_612453.1; NM_138444.3 UniGene; Hs.644125; - ProteinModelPortal; Q96CX2; - SMR; Q96CX2; - BioGrid; 125419; 24 IntAct; Q96CX2; 8 MINT; MINT-1159110; - STRING; 9606.ENSP00000317141; - iPTMnet; Q96CX2; - PhosphoSitePlus; Q96CX2; - BioMuta; KCTD12; - DMDM; 50401124; - REPRODUCTION-2DPAGE; IPI00060715; - EPD; Q96CX2; - MaxQB; Q96CX2; - PaxDb; Q96CX2; - PeptideAtlas; Q96CX2; - PRIDE; Q96CX2; - Ensembl; ENST00000377474; ENSP00000366694; ENSG00000178695 GeneID; 115207; - KEGG; hsa:115207; - UCSC; uc010aeu.2; human CTD; 115207; - DisGeNET; 115207; - GeneCards; KCTD12; - H-InvDB; HIX0171820; - HGNC; HGNC:14678; KCTD12 MIM; 610521; gene neXtProt; NX_Q96CX2; - OpenTargets; ENSG00000178695; - PharmGKB; PA25512; - eggNOG; KOG2723; Eukaryota eggNOG; ENOG410Z155; LUCA GeneTree; ENSGT00760000119013; - HOGENOM; HOG000041197; - HOVERGEN; HBG052218; - InParanoid; Q96CX2; - OMA; MLECIRG; - OrthoDB; EOG091G0P3F; - PhylomeDB; Q96CX2; - TreeFam; TF315332; - BioCyc; ZFISH:ENSG00000178695-MONOMER; - ChiTaRS; KCTD12; human GeneWiki; KCTD12; - GenomeRNAi; 115207; - PRO; PR:Q96CX2; - Proteomes; UP000005640; Chromosome 13 Bgee; ENSG00000178695; - CleanEx; HS_KCTD12; - ExpressionAtlas; Q96CX2; baseline and differential Genevisible; Q96CX2; HS GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell GO; GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell GO; GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB GO; GO:0051260; P:protein homooligomerization; IEA:InterPro InterPro; IPR000210; BTB/POZ_dom InterPro; IPR011333; SKP1/BTB/POZ InterPro; IPR003131; T1-type_BTB Pfam; PF02214; BTB_2; 1 SMART; SM00225; BTB; 1 SUPFAM; SSF54695; SSF54695; 1 1: Evidence at protein level; Acetylation; Cell junction; Cell membrane; Complete proteome; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse INIT_MET 1 1 Removed. CHAIN 2 325 BTB/POZ domain-containing protein KCTD12 /FTId=PRO_0000191295 MOD_RES 2 2 N-acetylalanine MOD_RES 119 119 Phosphotyrosine {ECO:0000250|UniProtKB:Q6WVG3} MOD_RES 151 151 Phosphoserine MOD_RES 171 171 Phosphoserine {ECO:0000250|UniProtKB:Q6WVG3} MOD_RES 185 185 Phosphoserine MOD_RES 196 196 Phosphothreonine {ECO:0000250|UniProtKB:Q6WVG3} MOD_RES 200 200 Phosphoserine {ECO:0000250|UniProtKB:Q6WVG3} SEQUENCE 325 AA; 35701 MW; 6254CC18E27275A9 CRC64; MALADSTRGL PNGGGGGGGS GSSSSSAEPP LFPDIVELNV GGQVYVTRRC TVVSVPDSLL WRMFTQQQPQ ELARDSKGRF FLDRDGFLFR YILDYLRDLQ LVLPDYFPER SRLQREAEYF ELPELVRRLG APQQPGPGPP PSRRGVHKEG SLGDELLPLG YSEPEQQEGA SAGAPSPTLE LASRSPSGGA AGPLLTPSQS LDGSRRSGYI TIGYRGSYTI GRDAQADAKF RRVARITVCG KTSLAKEVFG DTLNESRDPD RPPERYTSRY YLKFNFLEQA FDKLSESGFH MVACSSTGTC AFASSTDQSE DKIWTSYTEY VFCRE
Research Areas
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References

Drenos,F., et.al., Hum. Mol. Genet. 18 (12), 2305-2316 (2009)Suehara,Y., et.al., Clin. Cancer Res. 14 (6), 1707-1717 (2008)Cauchi,S., et.al., J. Mol. Med. 86 (3), 341-348 (2008)

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$ 80.00
Cat# BP9273c
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