|Other Names||ATP-binding cassette sub-family F member 1, ATP-binding cassette 50, TNF-alpha-stimulated ABC protein, ABCF1, ABC50|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9278b was selected from the C-term region of human ABCF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 2 is required for efficient Cap- and IRES- mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis.|
|Cellular Location||Isoform 2: Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope|
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Provided below are standard protocols that you may find useful for product applications.
The protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC proteins are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process.
Barcellos,L.F., et.al., PLoS Genet. 5 (10), E1000696 (2009)Paytubi,S., et.al., J. Biol. Chem. 284 (36), 24061-24073 (2009)Saito,A., et.al., J. Hum. Genet. 54 (6), 317-323 (2009)
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