|Other Names||Trans-1, 2-dihydrobenzene-1, 2-diol dehydrogenase, D-xylose 1-dehydrogenase, D-xylose-NADP dehydrogenase, Dimeric dihydrodiol dehydrogenase, Hum2DD, DHDH, 2DD|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9287a was selected from the N-term region of human DHDH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Small intestine.|
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Provided below are standard protocols that you may find useful for product applications.
DHDH encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction.
Guey,L.T., et.al, Eur. Urol. 57 (2), 283-292 (2010)Hosgood,H.D. et.al, Occup Environ Med 66 (12), 848-853 (2009)Hosgood,H.D. III, et.al, Respir Med 103 (12), 1866-1870 (2009)
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