|Other Names||Chitobiosyldiphosphodolichol beta-mannosyltransferase, Asparagine-linked glycosylation protein 1 homolog, Beta-1, 4-mannosyltransferase, GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase, GDP-mannose-dolichol diphosphochitobiose mannosyltransferase, Mannosyltransferase-1, MT-1, hMat-1, ALG1, HMAT1, HMT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The enzyme encoded by this protein catalyzes the first mannosylation step in the biosynthesis of lipid-linked oligosaccharides. This protein is mutated in congenital disorder of glycosylation type Ik.
Grubenmann,C.E. Hum. Mol. Genet. 13 (5), 535-542 (2004)Kranz,C. Am. J. Hum. Genet. 74 (3), 545-551 (2004)Schwarz,M. Am. J. Hum. Genet. 74 (3), 472-481 (2004)
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