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ITPKC Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96DU7 |
|---|
| Gene ID | 80271 |
|---|---|
| Other Names | Inositol-trisphosphate 3-kinase C, Inositol 1, 5-trisphosphate 3-kinase C, IP3 3-kinase C, IP3K C, InsP 3-kinase C, ITPKC, IP3KC |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ITPKC (HGNC:14897) |
|---|---|
| Synonyms | IP3KC |
| Function | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5- trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis (PubMed:11085927, PubMed:12747803). Can phosphorylate inositol 2,4,5- triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity). |
| Cellular Location | Nucleus. Cytoplasm. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity {ECO:0000250|UniProtKB:Q80ZG2} |
| Tissue Location | Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ITPKC encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.
References
Chi,H. Hum. Mol. Genet. 19 (6), 1147-1151 (2010)Onouchi,Y. Nat. Genet. 40 (1), 35-42 (2008)Nalaskowski,M.M. Biol. Chem. 387 (5), 583-593 (2006)
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