|Other Names||Inositol-trisphosphate 3-kinase C, Inositol 1, 5-trisphosphate 3-kinase C, IP3 3-kinase C, IP3K C, InsP 3-kinase C, ITPKC, IP3KC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.|
|Cellular Location||Nucleus. Cytoplasm. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity|
|Tissue Location||Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain|
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Provided below are standard protocols that you may find useful for product applications.
ITPKC encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.
Chi,H. Hum. Mol. Genet. 19 (6), 1147-1151 (2010)Onouchi,Y. Nat. Genet. 40 (1), 35-42 (2008)Nalaskowski,M.M. Biol. Chem. 387 (5), 583-593 (2006)
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