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IL31 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6EBC2
Peptide ID 34490
Additional Information
Gene ID 386653
Other Names Interleukin-31, IL-31, IL31
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL31
Function Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).
Cellular Location Secreted.
Tissue Location Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.
Research Areas
Citations (0)

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Background

IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma.

References

Le Saux, S., et al. J. Biol. Chem. 285(5):3470-3477(2010)Zucchelli, M., et al. Inflamm. Bowel Dis. 15(7):961-962(2009)Gutzmer, R., et al. J. Allergy Clin. Immunol. 123(3):619-625(2009)Zhang, Q., et al. Cytokine Growth Factor Rev. 19 (5-6), 347-356 (2008) :Werfel, T., et al. Chem Immunol Allergy 94, 101-111 (2008) :

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$ 80.00
Cat# BP9388a
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