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IL31 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6EBC2 |
|---|
| Gene ID | 386653 |
|---|---|
| Other Names | Interleukin-31, IL-31, IL31 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | IL31 |
|---|---|
| Function | Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity). |
| Cellular Location | Secreted. |
| Tissue Location | Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma.
References
Le Saux, S., et al. J. Biol. Chem. 285(5):3470-3477(2010)Zucchelli, M., et al. Inflamm. Bowel Dis. 15(7):961-962(2009)Gutzmer, R., et al. J. Allergy Clin. Immunol. 123(3):619-625(2009)Zhang, Q., et al. Cytokine Growth Factor Rev. 19 (5-6), 347-356 (2008) :Werfel, T., et al. Chem Immunol Allergy 94, 101-111 (2008) :
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