|Other Names||Complexin-1, Complexin I, CPX I, Synaphin-2, CPLX1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity).|
|Cellular Location||Cytoplasm, cytosol. Note=Enriched at synaptic-releasing sites in mature neurons|
|Tissue Location||Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease|
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Provided below are standard protocols that you may find useful for product applications.
CPLX1 encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release.
Salimi, K., et al. Synapse 62(4):273-282(2008)Giraudo, C.G., et al. Science 313(5787):676-680(2006)Kishi, T., et al. Schizophr. Res. 82 (2-3), 185-189 (2006) :Basso, M., et al. Proteomics 4(12):3943-3952(2004)Chen, X., et al. Neuron 33(3):397-409(2002)
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