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ELAC2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BQ52 |
|---|
| Gene ID | 60528 |
|---|---|
| Other Names | Zinc phosphodiesterase ELAC protein 2, ElaC homolog protein 2, Heredity prostate cancer protein 2, Ribonuclease Z 2, RNase Z 2, tRNA 3 endonuclease 2, tRNase Z 2, ELAC2, HPC2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ELAC2 |
|---|---|
| Synonyms | HPC2 |
| Function | Zinc phosphodiesterase, which displays mitochondrial tRNA 3'- processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (PubMed:21593607). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly (PubMed:24703694). |
| Cellular Location | Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Nucleus Note=Mainly mitochondrial |
| Tissue Location | Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ELAC2 has a C-terminal domain with tRNA; processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest.
References
Beuten, J., et al. Cancer Epidemiol. Biomarkers Prev. 19(2):588-599(2010)Elbarbary, R.A., et al. FEBS Lett. 583(19):3241-3246(2009)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Noda, D., et al. Oncogene 25(41):5591-5600(2006)Takaku, H., et al. Nucleic Acids Res. 31(9):2272-2278(2003)
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